Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC027
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-06-17 11:23
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 250mg 3 x 1/4 caps Madopar HBS 2x evening

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 5 individuals with a value less than 0.52 were subsequently diagnosed with PD. That is, 11.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.52 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 39, 'TN': 27, 'TP': 3, 'FP': 3}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 17, 'TP': 19, 'FP': 13}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 12, 'TN': 9, 'TP': 30, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.708
timePerCircleCoV 0.297952
timePerCircleSlope -0.093011
meanError 1.47211
tremorFreq 6.54297
tremorRelPower 90.3853
tremorGyroAmpMean 0.332286
tremorGyroAmpSlope -0.00438356
tremorGyroAmpCoV 0.323694
tremorCoordAmpMean 0.202886
tremorCoordAmpSlope 0.00277608
tremorCoordAmpCoV 0.405317
tremorAccAmpMean 0.177737
tremorAccAmpSlope 0.00194876
tremorAccAmpCoV 0.39183
tremorPcRelVar 0.774321
tremorPcX -0.940094
tremorPcY 0.340914

Circle Segment 1

Duration 13.48 s, Accuracy Estimate 1.184 (lower is better)

Circle Segment 2

Duration 11.92 s, Accuracy Estimate 1.134 (lower is better)

Circle Segment 3

Duration 10.96 s, Accuracy Estimate 1.226 (lower is better)

Circle Segment 4

Duration 9.08 s, Accuracy Estimate 1.754 (lower is better)

Circle Segment 5

Duration 8.08 s, Accuracy Estimate 1.532 (lower is better)

Circle Segment 6

Duration 6.88 s, Accuracy Estimate 1.401 (lower is better)

Circle Segment 7

Duration 7.28 s, Accuracy Estimate 1.462 (lower is better)

Circle Segment 8

Duration 7.16 s, Accuracy Estimate 1.436 (lower is better)

Circle Segment 9

Duration 6.72 s, Accuracy Estimate 1.36 (lower is better)

Circle Segment 10

Duration 5.52 s, Accuracy Estimate 2.232 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 21.2844
timePerSpiralCoV 0.127077
timePerSpiralSlope -0.0185425
meanError 2.25671
tremorFreq 6.54297
tremorRelPower 86.0708
tremorGyroAmpMean 0.357633
tremorGyroAmpSlope 0.0017673
tremorGyroAmpCoV 0.28148
tremorCoordAmpMean 0.363168
tremorCoordAmpSlope 0.00135885
tremorCoordAmpCoV 0.236909
tremorAccAmpMean 0.307205
tremorAccAmpSlope 0.00115838
tremorAccAmpCoV 0.246787
tremorPcRelVar 0.715311
tremorPcX -0.986887
tremorPcY 0.161415

Spiral Segment 1

Duration 27.6 s, Accuracy Estimate 2.047 (lower is better)

Spiral Segment 2

Duration 19.68 s, Accuracy Estimate 2.036 (lower is better)

Spiral Segment 3

Duration 18.48 s, Accuracy Estimate 2.521 (lower is better)

Spiral Segment 4

Duration 21.64 s, Accuracy Estimate 2.105 (lower is better)

Spiral Segment 5

Duration 20.4 s, Accuracy Estimate 2.226 (lower is better)

Spiral Segment 6

Duration 22.88 s, Accuracy Estimate 2.883 (lower is better)

Spiral Segment 7

Duration 20.44 s, Accuracy Estimate 1.961 (lower is better)

Spiral Segment 8

Duration 21.16 s, Accuracy Estimate 2.52 (lower is better)

Spiral Segment 9

Duration 19.28 s, Accuracy Estimate 2.012 (lower is better)

Elel

eDurationMean 0.748514
eDurationStd 0.224854
eDurationStdnorm 0.300401
eDurationMedian 0.71
eDurationQuartdelta 0.305
eDurationQuartdeltanorm 0.429577
eDurationKurt 4.04778
eDurationTrenddiff -0.1275
eDurationTrendratio 0.829431
eWidthMean 6.55832
eWidthStd 1.76816
eWidthStdnorm 0.269605
eWidthMedian 6.318
eWidthQuartdelta 1.8135
eWidthQuartdeltanorm 0.287037
eWidthKurt 4.27684
eWidthTrenddiff -0.6435
eWidthTrendratio 0.902655
eHeightMean 12.0984
eHeightStd 5.9662
eHeightStdnorm 0.493138
eHeightMedian 10.998
eHeightQuartdelta 3.9195
eHeightQuartdeltanorm 0.356383
eHeightKurt 8.99803
eHeightTrenddiff -3.4515
eHeightTrendratio 0.737778
eAspectMean 0.626846
eAspectStd 0.29135
eAspectStdnorm 0.464787
eAspectMedian 0.553191
eAspectQuartdelta 0.197276
eAspectQuartdeltanorm 0.356615
eAspectKurt 14.6973
eAspectTrenddiff 0.175037
eAspectTrendratio 1.35315
eSlantMean 0.0822316
eSlantStd 0.321825
eSlantStdnorm 3.91365
eSlantMedian 0.119403
eSlantQuartdelta 0.268166
eSlantQuartdeltanorm 2.24589
eSlantKurt 13.0768
eSlantTrenddiff 0.0184847
eRtopMean 0.703409
eRtopStd 0.208889
eRtopStdnorm 0.296967
eRtopMedian 0.741935
eRtopQuartdelta 0.320817
eRtopQuartdeltanorm 0.432405
eRtopKurt 4.54494
eRtopTrenddiff 0.0373893
eRbotMean 0.509583
eRbotStd 0.27069
eRbotStdnorm 0.5312
eRbotMedian 0.509804
eRbotQuartdelta 0.385866
eRbotQuartdeltanorm 0.75689
eRbotKurt 2.69332
eRbotTrenddiff -0.160617
eRrightMean 0.735178
eRrightStd 0.29347
eRrightStdnorm 0.399183
eRrightMedian 0.820896
eRrightQuartdelta 0.218196
eRrightQuartdeltanorm 0.265802
eRrightKurt 10.5757
eRrightTrenddiff 0.0784263
eRleftMean 0.421324
eRleftStd 0.195332
eRleftStdnorm 0.463614
eRleftMedian 0.426471
eRleftQuartdelta 0.272004
eRleftQuartdeltanorm 0.637801
eRleftKurt 3.33838
eRleftTrenddiff 0.0322331
lDurationMean 1.12941
lDurationStd 0.258963
lDurationStdnorm 0.22929
lDurationMedian 1.1525
lDurationQuartdelta 0.32
lDurationQuartdeltanorm 0.277657
lDurationKurt 3.0388
lDurationTrenddiff -0.18
lDurationTrendratio 0.848739
lWidthMean 14.1088
lWidthStd 3.50185
lWidthStdnorm 0.248203
lWidthMedian 13.806
lWidthQuartdelta 4.797
lWidthQuartdeltanorm 0.347458
lWidthKurt 2.5921
lWidthTrenddiff 3.51
lWidthTrendratio 1.28571
lHeightMean 32.0374
lHeightStd 5.8342
lHeightStdnorm 0.182106
lHeightMedian 31.4145
lHeightQuartdelta 6.084
lHeightQuartdeltanorm 0.193669
lHeightKurt 4.08661
lHeightTrenddiff -1.521
lHeightTrendratio 0.952899
lAspectMean 0.442494
lAspectStd 0.0902589
lAspectStdnorm 0.203978
lAspectMedian 0.4241
lAspectQuartdelta 0.0989222
lAspectQuartdeltanorm 0.233252
lAspectKurt 2.92479
lAspectTrenddiff 0.0574731
lAspectTrendratio 1.14087
lSlantMean 0.282788
lSlantStd 0.139058
lSlantStdnorm 0.491739
lSlantMedian 0.30142
lSlantQuartdelta 0.167026
lSlantQuartdeltanorm 0.554131
lSlantKurt 3.37414
lSlantTrenddiff 0.114874
lRtopMean 0.864813
lRtopStd 0.0864137
lRtopStdnorm 0.0999219
lRtopMedian 0.875406
lRtopQuartdelta 0.102883
lRtopQuartdeltanorm 0.117526
lRtopKurt 3.15329
lRtopTrenddiff 0.0578998
lRbotMean 0.247533
lRbotStd 0.165765
lRbotStdnorm 0.669668
lRbotMedian 0.211693
lRbotQuartdelta 0.187199
lRbotQuartdeltanorm 0.884295
lRbotKurt 8.40263
lRbotTrenddiff -0.103739
lRrightMean 0.913312
lRrightStd 0.05225
lRrightStdnorm 0.0572094
lRrightMedian 0.921164
lRrightQuartdelta 0.0666361
lRrightQuartdeltanorm 0.072339
lRrightKurt 2.98637
lRrightTrenddiff 0.0181409
lRleftMean 0.203766
lRleftStd 0.111291
lRleftStdnorm 0.546168
lRleftMedian 0.167893
lRleftQuartdelta 0.111658
lRleftQuartdeltanorm 0.665054
lRleftKurt 3.402
lRleftTrenddiff -0.0489426

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

Elel Segment 17

Elel Segment 18

FITTS Short Modified

meanTouchScore 0.877674
sumTouchScores 17.5535
meanMovementTime 0.868158
numTouches 20
undershootPercentage 0
overshootPercentage 10

FITTS Long Modified

meanTouchScore 0.702443
sumTouchScores 11.9415
meanMovementTime 1.24094
numTouches 17
undershootPercentage 11.7647
overshootPercentage 41.1765

ZigZag

numZigzags 5
timePerZigzagMean 16.376
timePerZigzagCoV 0.191503
timePerZigzagSlope -0.0615535
meanError 2.51343
tremorFreq 6.73828
tremorRelPower 53.4642
tremorGyroAmpMean 0.301389
tremorGyroAmpSlope 0.00361636
tremorGyroAmpCoV 0.142574
tremorCoordAmpMean 0.551931
tremorCoordAmpSlope 0.00483463
tremorCoordAmpCoV 0.204486
tremorAccAmpMean 0.45793
tremorAccAmpSlope 0.00498056
tremorAccAmpCoV 0.197592
tremorPcRelVar 0.605443
tremorPcX 0.948112
tremorPcY 0.317935

ZigZag Segment 1

Duration 21.44 s, Accuracy Estimate 2.116 (lower is better)

ZigZag Segment 2

Duration 15.04 s, Accuracy Estimate 2.445 (lower is better)

ZigZag Segment 3

Duration 14.76 s, Accuracy Estimate 2.393 (lower is better)

ZigZag Segment 4

Duration 13.44 s, Accuracy Estimate 2.84 (lower is better)

ZigZag Segment 5

Duration 17.2 s, Accuracy Estimate 2.773 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 18.728
timePerZigzagCoV 0.209755
timePerZigzagSlope -0.124519
zigzagHeightMean 84.7682
zigzagHeightCoV 0.0359877
zigzagHeightSlope 0.0168212
meanError 0.0449329
tremorFreq 6.73828
tremorRelPower 85.9358
tremorGyroAmpMean 0.279334
tremorGyroAmpSlope 0.00438597
tremorGyroAmpCoV 0.200675
tremorCoordAmpMean 0.588922
tremorCoordAmpSlope 0.00628439
tremorCoordAmpCoV 0.181975
tremorAccAmpMean 0.494045
tremorAccAmpSlope 0.00685198
tremorAccAmpCoV 0.175747
tremorPcRelVar 0.5256
tremorPcX -0.510714
tremorPcY 0.859751

ZigZag Offset Segment 1

Duration 24.44 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 2

Duration 21.0 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 17.36 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 4

Duration 15.12 s, Accuracy Estimate 0.062 (lower is better)

ZigZag Offset Segment 5

Duration 15.72 s, Accuracy Estimate 0.05 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.53}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.52}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7398306180391163}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8813353762088514}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4877726555217643}